340041-91-0

The transcription factor AP-1 (activator protein-1) is involved in cellular proliferationtransformation and death. AP-1 and nuclear factor B (NF- B) can be specifically targeted to prevent cancer induction in mouse models. AP-1 can be produced by 18 different dimeric combinations of proteins from the Jun (c-JunJunB and JunD) and Fos (c-FosFosBFra-1 and Fra-2) familiesincluding Jun homodimers and Jun-Fos heterodimers. The Jun and Fos proteins contain a basic-region leucine zipper (bZIP) domainand are capable of binding to other bZIP proteins including those from the ATFMAFCNC and C/EBP (CCAAT/enhancer-binding protein) subfamilies (5]) Jun-Jun and Jun-Fos dimers bind with highest affinity to the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (TRE) [TGA(C/G)TCA]although many other μAP-1-like sitesμ have been reported. Binding to any of these sites can be tissue-specificor affected by neighboring sequencesand dependent upon interactions with