Sabinene is a bicyclic monoterpene found in a variety of plants, including
Cannabis, that has antifungal and anti-inflammatory properties.
1,2,3 It inhibits the growth of various fungi
in vitro, including several species of
Candida,
Trichophyton, and
Aspergillus (MICs = 0.16-5 μl/ml).
3 Sabinene (0.32 μl/ml) prevents increases in nitrite production in RAW 264.7 macrophages stimulated by LPS and IFN-γ. It is cytotoxic to RAW 264.7 macrophages and HaCat keratinocytes when used at a concentration of 1.25 μl/ml. Formulations containing sabinene have been used as perfume additives.
