332173-89-4

SD-70 is an inhibitor for histone demethylase JMJD2C and exhibits antitumor efficacy. SD-70 inhibits viability of cancer cells CWR22Rv1 (9% cell survival at 10 μM), PC3 (14% cell survival at 2 μM) and DU145 (26% cell survival at 2 μM)[1].

ChEBI:N-[2-furanyl-(8-hydroxy-7-quinolinyl)methyl]-2-methylpropanamide is a hydroxyquinoline.

Cell permeable: yes''Primary Target
JMJD2C/KDM4C''Reversible: yes

[1] Xie M, et al., Inhibitors of jmjd2c as anticancer agents. WO2015167874.