331467-05-1

Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1].

Cell permeable: no''Primary Target
CDK1''Product competes with ATP.''Reversible: yes''Target IC50: 5 nM7 nM80 nMagainst Cdk1Cdk5and glycogen synthase kinase-3β (GSK-3β)respectively

CDK1: 5 nM (IC₅₀); CDK5: 7 nM (IC₅₀); GSK-3β: 80 nM (IC₅₀)

[1] Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors. J Biol Chem. 2001 Jan 5;276(1):251-60. DOI:10.1074/jbc.M002466200