331467-03-9

5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively[1].

GSK-3β: 9 nM (IC₅₀); Cdk5/p25: 20 nM (IC₅₀); Cdk1/cyclin B: 25 nM (IC₅₀)

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[1] Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60. DOI:10.1074/jbc.M002466200