ChemicalBook CAS DataBase List 32909-05-0

32909-05-0

Name	N4-ACETYL-2'-DEOXYCYTIDINE
CAS	32909-05-0
EINECS(EC#)	2017-001-1
Molecular Formula	C11H15N3O5
MDL Number	MFCD00057435
Molecular Weight	269.25
MOL File	32909-05-0.mol

Chemical Properties

Melting point	150-152 °C
density	1.60±0.1 g/cm3(Predicted)
storage temp.	Store at 0°C
solubility	DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated), Water (Slightly)
form	lyophilized
pka	10.28±0.20(Predicted)
color	White to Off-White
Stability:	Hygroscopic

Safety Data

Hazard Codes	Xi
Risk Statements	36/37/38 less more
Safety Statements	26 less more
RIDADR	UN 3264 8 / PGIII
WGK Germany	3

Hazard Information

Uses

Human ADIPOQ / Adiponectin ELISA Kit has been used in the quantification of leptin and adiponectin from serum and plasma samples.

Definition

ChEBI: N(4)-acetyl-2'-deoxycytidine is 2'-deoxyytidine in which one of the exocyclic amino hydrogens is substituted by an acetyl group. It is a secondary carboxamide and a pyrimidine 2'-deoxyribonucleoside.

General Description

Rat gAcrp30 (amp-1) is a 16.6 kDa protein that corresponds to the C-terminal globular domain of adiponectin (amp-1). gAcrp30/Adipolean is expressed and secreted exclusively by adipose tissue. This protein possesses unique pharmacological properties for regulation of body weight and lipid metabolism. It is a key component in controlling energy homeostasis. Recently, gAcrp30/Adipolean has been shown to inhibit the proliferation of myelomonocytic progenitors. The Recombinant rat gAcrp30/Adipolean is a 16.6 kDa protein consisting of 145 amino acid residues.

Biochem/physiol Actions

In obese mice and humans, adiponectin/gAcrp30 (adipocyte complement-related protein) mRNA expression is reduced, therefore linking this hormone to energy homeostasis. In incubated mouse muscle and cultured cells, gAcrp30 leads to an increase in fatty acid oxidation. This hormone is also linked to anti-atherogenesis, and in apoE-deficient mice, overexpression of gAcrp30 results in significant attenuation of atherosclerosis. Long-term administration of this hormone in mice results in weight loss without reduction in food intake. This hormone is capable of reducing proliferation of MDA-ERα7 cell line. Studies show that ratio of gAcrp30 to leptin and the ERα (estrogen receptor) status of cells are key in determining BRCA (breast cancer) cell growth.

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