ChemicalBook CAS DataBase List 327177-34-4

327177-34-4

Name	TCY-NH2
CAS	327177-34-4
Molecular Formula	C40H49N7O7
MDL Number	MFCD06798369
Molecular Weight	739.86
MOL File	327177-34-4.mol

Chemical Properties

storage temp.	−20°C
form	Powder
Water Solubility	Soluble to 1 mg/ml in water

Safety Data

Safety Statements

22-24/25

Hazard Information

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Animal Model:	Brain death (BD) rat model^[3]
Dosage:	0.6 mg/kg for a single dose
Administration:	Tail vein injection for a single dose
Result:	Reduced blood platelet activation and hepatic platelet accumulation. Attenuated the inflammatory response and apoptosis in the livers. Inhibited the activation of NF-κB and MAPK pathways induced by Brain death (BD).

Animal Model:	Burn injury model of C57BL/6 N mice^[4]
Dosage:	0.6 mg/kg for a single dose
Administration:	Intraperitoneal injection
Result:	Increased expression and phosphorylation of PKC-θ in the presence of platelets, without affecting early posttraumatic hemostasis.

Animal Model:	BALB/c mice^[6]
Dosage:	40 ng/kg for a single dose
Administration:	Intrapleural injection
Result:	Abolished the number of rolling and adhering neutrophils on the vessel wall. Inhibited CXCL8- and Cg-induced neutrophil migration into the pleural cavity of mice.

327177-34-4

Chemical Properties

Safety Data

Hazard Information

Uses

in vivo

IC 50

storage

Supplier

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