32450-25-2

Cochlioquinone A is an antagonist of CCR5. Diacylglycerol kinase inhibitor.

Cochlioquinone A is the major component of a bioactive pigment isolated from Bipolaris leersia. Cochlioquinone A has recently been shown to be an antagonist of the human chemokine receptor, CCR5, in HIV-1,). Cochlioquinone A is anti-angiogenic and exhibits inhibitory activity against diacylglycerol acyltransferase and NADH-ubiquinone reductase.

Cochlioquinone A, a bioactive compound isolated from D. sacchari and Bipolaris sp., is an inhibitor of diacylglycerol kinase (DGK; Ki = 3.1 μM) and diacylglycerol acyltransferase (DGAT; IC50 = 5.6 μM). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma with an IC50 value of 3 μM. It is also reported to compete with macrophage inflammatory protein-1α for binding to human CCR5 chemokine receptors with an IC50 value of 11 μM.[Cayman Chemical]

ChEBI:Cochlioquinone A is a member of oxanes.

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