32421-46-8

Bunaftine,Malesci

ChEBI: Bunaftine is a naphthalenecarboxamide.

Into a solution containing α-naphthoic acid chloride in benzene with agitation and cooling for 0.5 h a benzene solution of N,N-diethylamine-ethyl-N'-(nbutyl) amine is dropped. As the dropping is ended, the solution is kept under agitation in a water bath for 3 h.
After cooling the benzene solution is extracted with 10% hydrochloric acid; then the aqueous solution is saturated with potassium carbonate. The separated oil is extracted with ether and, after drying on sodium sulfate, the solvent is removed and the residue is vacuum distilled. So the N-(2- diethylamino-ethyl)-N-(n-butyl)-1-naphthalenecarboxamide, boiling point 178°C/0.1 mm/Hg.

Antiarrhythmic