Production Methods
Commercial production of dinex diclexine would have followed the same chemical processes used for mid 20th century nitrophenol amine salts. Industrial manufacture began with synthesis of the dinitrophenol component, produced by controlled nitration of a cyclohexyl substituted phenol. In parallel, dicyclohexylamine was prepared or procured. The two components were then combined in a neutralisation/salt formation step, typically in an organic solvent, to yield the stable dinex diclexine complex. Downstream processing involved filtration, drying, milling, and quality control assays to produce technical grade material.
