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ChEBI: An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of propionic acid.

03:0 Coenzyme A acts as a substrate for methyl citrate synthase (PrpC)an important enzyme involved in tricarboxylic acid (TCA) cycle. It is a metabolic intermediate in the 1,2-propanediol and propionate degradation pathway of Salmonella enterica serovar Typhimurium LT2. Accumulation of propanoyl coenzyme A due to the deficiency of propionyl-coenzyme A (CoA) carboxylase causes propionic acidemia (PA).