ChemicalBook CAS DataBase List 31692-85-0

31692-85-0

Name	GLYCOFUROL
CAS	31692-85-0
EINECS(EC#)	203-989-9
Molecular Formula	C11H21O5R
MDL Number	MFCD00801146
Molecular Weight	233.28
MOL File	31692-85-0.mol

Chemical Properties

Appearance	liquid
Melting point	≤ -100 °C
Boiling point	100-145 °C0.4 mm Hg
density	1.09 g/mL at 25 °C(lit.)
vapor pressure	4.97-37.4Pa at 20-50℃
refractive index	n20/D 1.462(lit.)
Fp	>230 °F
storage temp.	Store below +30°C.
solubility	Chloroform (Sparingly), Methanol (Slightly, Sonicated)
form	Oil
color	Colourless
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	water: soluble 3420g/L
α-end	tetrahydrofurfuryl ether
Ω-end	hydroxyl
LogP	-1.21--0.38

Safety Data

WGK Germany	3
RTECS	MD0907500
HS Code	3907 20 20

Hazard Information

Chemical Properties

liquid

Uses

Glycofurol is used as a carrier device for drug delivery.

Production Methods

Glycofurol is prepared by the reaction of tetrahydrofurfuryl alcohol with ethylene oxide (followed by a special purification process in the case of Glycofurol 75).

Pharmaceutical Applications

Glycofurol is used as a solvent in parenteral products for intravenous or intramuscular injection in concentrations up to 50% v/v. It has also been investigated, mainly in animal studies, for use as a penetration enhancer and solvent in topical and intranasal formulations. Glycofurol has also been used at 20% v/v concentration in a rectal formulation.

Biological Activity

Liquid glycofurol can readily transform into gel systems with excellent elasticity due to whichit can be used as a medium to dissolve water-insoluble drugs.

Safety

Glycofurol is mainly used as a solvent in parenteral pharmaceutical formulations and is generally regarded as a relatively nontoxic and nonirritant material at the levels used as a pharmaceutical excipient. Glycofurol can be irritant when used undiluted; its tolerability is approximately the same as propylene glycol.
Glycofurol may have an effect on liver function and may have a low potential for interaction with hepatoxins or those materials undergong extensive hepatic metabolism.
LD50 (mouse, IV): 3.5 mL/kg

storage

Stable if stored under nitrogen in a well-closed container protected from light, in a cool, dry place.

Incompatibilities

Incompatible with oxidizing agents.

Regulatory Status

Included in parenteral medicines licensed in Europe.

Spectrum Detail

Supplier

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ROSEWA HOLDING GROUP CO.,LIMITED

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