312622-77-8

Name	cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS	312622-77-8
Molecular Formula	C19H21N3O7
Molecular Weight	403.39
MOL File	312622-77-8.mol

Synonyms

VU0090157 VU-0090157 VU 0090157 cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-, cyclopentyl ester

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Hazard Information

Description

VU0090157 is a novel allosteric potentiators of M1 muscarinic receptor which may provide novel treatments for schizophrenia and Alzheimer's disease.

Uses

VU0090157 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR). VU0090157 increases the affinity of ACh by binding to the allosteric site. VU0090157 can be used in the study of schizophrenia and Alzheimer's disease[1].

References

[1] Marlo J E, et al. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity[J]. Molecular pharmacology, 2009, 75(3): 577-588. DOI:10.1124/mol.108.052886

Supplier

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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