AD16 (Acetamide) is a LINE-1 retrotransposon endonuclease inhibitor with the IC50 of 4.7 μM. AD16 (Acetamide) reduce LINE-1 retrotransposition, L1-induced DNA damage, and inflammation reinforced by L1 in senescent cells[1].
References
[1] D'Ordine AM, et al. Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease. Nat Commun. 2024;15(1):3883. Published 2024 May 8. DOI:10.1038/s41467-024-48066-x
