DOPE-C8 is a zwitterionic glycerophospholipid that has been used in the generation of lipid nanoparticles (LNPs) for mRNA delivery in vivo.1 LNPs containing DOPE-C8 have improved endosomal escape ability over LNPs containing 1,2-DSPC (Item Nos. 15100 | 39189). LNPs containing DOPE-C8 and encapsulating mRNA encoding EGFP induce hepatic EGFP expression in mice.WARNING This product is not for human or veterinary use.
References
[1] KAZUKI IWAKAWA. Cubic Phase-Inducible Zwitterionic Phospholipids Improve the Functional Delivery of mRNA[J]. Advanced Science, 2025, 12 17. DOI: 10.1002/advs.202413016
