307525-40-2

IMB-10 may be used to study integrin-mediated signaling in tumor cells.

IMB-10 is a ligand for the αMβ2 integrin th at stabilizes the binding of the integrin to endogenous ligands such as proMMP-9 and fibrinogen. IMB-10 blocks migration of lymphocyte cell lines and inhibits leukocyte infiltration in a murine thioglycolate-induced peritonitis. ''IMB-10 is a thioxothiazolidine compound th at inhibits the infiltration of leukocytes to the site of tumor and blocks the invasion of HSC-3 carcinoma. It modulates the host inflammatory responses and tumor progression.