General Description
Colorless nonflammable gas. Nearly odorless.
Reactivity Profile
2,2-DICHLORO-1,1,1-TRIFLUOROETHANE is chemically inert in many situations, but can react violently with strong reducing agents such as the very active metals and the active metals. They suffer oxidation with strong oxidizing agents and under extremes of temperature.
Chemical Properties
1,1-Dichloro-2,2,2-trifluoroethane has a light ethereal odor
with poor warning properties.
Uses
HCFC 123 is an interim replacement for the CFCs and is
scheduled for a production phase-out during the 2020s.
Its main application is as a substitute for CFC 11 in centrifugal
chillers used for air conditioning of large buildings. It is
also used in smaller air-conditioning units, and may have
applications in foam blowing, and firefighting and as a
chemical intermediate.
Health Hazard
HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) has evidenced significant human liver toxicity. A group of 17 workers suffered liver damage in a 1997 outbreak. They were involved in containerizing this liquid. HCFC-123 is chemically similar to halothane and has the same toxic metabolite. HCFC- 123 exposure also was implicated as the cause of liver disease in nine industrial workers who had repeated exposure because of a leaking airconditioning system in 1996; the refrigerant also contained HCFC-124. HCFC-124 and HCFC-125 are also structurally similar to halothane.
Flammability and Explosibility
Nonflammable
Carcinogenicity
An inhalation toxicity/oncogenicity
study was conducted with groups of 80 male and
80 female rats. This study was described earlier in this
section. In addition to the effects on serum chemistry parameters
and the retina, increases in benign tumors of the
pancreas, testes, and liver were reported. As noted above, the survival in
the HCFC 123–exposed animals was better than in the airexposed
controls. These tumors tended to appear near the end of the study and generally were not considered to be the cause
of death.
