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CAS DataBase List
3043685-80-6
3043685-80-6
Name
SHP2-IN-32
CAS
3043685-80-6
Molecular Formula
C29H27ClN6O2S
Molecular Weight
559.08
MOL File
3043685-80-6.mol
Synonyms
SHP2-IN-32
3-Pyridinecarboxamide, N-[3-[[5-[(1S)-1-amino-1,3-dihydrospiro[2H-indene-2,4′-piperidin]-1′-yl]-2-pyrazinyl]thio]-2-chlorophenyl]-4-hydroxy-
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Chemical Properties
Boiling point
774.0±60.0 °C(predicted)
density
1.49±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka
11.58±0.70(predicted)
Hazard Information
Uses
SHP2-IN-32 (compound C6) is an orally active, allosteric SHP2 inhibitor with an IC50 value of 0.13 nM. SHP2-IN-32 exhibits antitumor activity[1].
References
[1] Lv X, et al. Discovery of novel substituted pyridine carboxamide derivatives as potent allosteric SHP2 inhibitors. Eur J Med Chem. 2024 Sep 5;279:116830. DOI:
10.1016/j.ejmech.2024.116830
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TargetMol Chemicals Inc.
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15002134094
Website
https://www.targetmol.cn/
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