Description
L1Au2 is a dual inhibitor of EGFR and thioredoxin reductase (TrxR; IC50 = 0.99 µM).{72756|} It inhibits the phosphorylation of EGFR, Akt, and ERK in PC-9 lung cancer cells, which express EGFR containing the exon 19 deletion, when used at concentrations of 0.01 or 0.05 µM. L1Au2 inhibits the proliferation of PC-9 and gefitinib-resistant PC-9 cells (IC50s = 0.012 and 1.76 µM, respectively) and induces ferroptosis in gefitinib-resistant PC-9 cells. In vivo, L1Au2 (10 mg/kg) decreases tumor weight and intratumoral glutathione peroxidase 4 (Gpx4) levels in a gefitinib-resistant PC-9 mouse xenograft model.WARNING This product is not for human or veterinary use.
