PDE4B/D-IN-3 (example 22) is a potent inhibitor of PDE4, with IC50s of 0.071 nM and 0.09 nM for PDE4B2 and PDE4D, respectively[1].
IC 50
PDE4B: 0.071 nM (IC50); PDE4D: 0.09 nM (IC50)
References
[1] Suzhou Ark Biopharmaceutical Co., Ltd. Aza-fused ring compound, preparation method therefor, and use thereof in medicine. World Intellectual Property Organization, WO2024067660 A1 2024-04-04
