SPOP-IN-2 (compound E1) is a Speckle-type POZ protein (SPOP) inhibitor with IC50 of 0.58 μM, which disrupt the SPOP-subtrate interaction and selectively inhibits proliferation of ccRCC[1].
References
[1] Zhou C, et al., Synthesis and Biological Evaluation of β-Lactam Derivatives Targeting Speckle-Type POZ Protein (SPOP). ACS Med Chem Lett. 2024 Jan 25;15(2):270-279. DOI:10.1021/acsmedchemlett.3c00515
