303-01-5

Name	hydroxydione
CAS	303-01-5
Molecular Formula	C21H32O3
MDL Number	MFCD00199962
Molecular Weight	332.48
MOL File	303-01-5.mol

Synonyms

hydroxydione 5beta-dihydrodeoxycorticosterone Pregnane-3,20-dione, 21-hydroxy-, (5β)- 17β-(Hydroxyacetyl)-5β-androstane-3-one

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Safety Data

HS Code

2924199090

Hazard Information

Uses

Hydroxydione is one of the chemicals studied for acute oral toxicity, repellency and hazard potential to species of wild and domestic birds.

Definition

ChEBI: A 3-oxo steroid with 5beta-configuration formed from 11-deoxycorticosterone by reduction across the C4-C5 double bond.

in vivo

Hydroxydione increases the duration of hexobarbital narcosis and repeats hexobarbital doses decrease the duration of hydroxydione narcosis^[1]. Hydroxydione (5-100 mg/kg; i.v. once) produces a transient hypotension with little bradycardia and affects the respiration^[2].

Animal Model:	Cats with chloralose 60 to 80 mg/kg^[2]
Dosage:	5-100 mg/kg
Administration:	Intravenous injection; 5-100 mg/kg once
Result:	Produce severe respiratory depression, but showed no effect on the tibialis in response to excitation of its motor nerve under the condition of chloralose. Produced the usual substantial sustained hypotension seen in chloralosed cats to response the nictitating membrane to preganglionic excitation with a dose of 10 mg/kg. Repressed the respiration in chloralosed cats after a rapid injection.

Supplier

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

LGC Science (Shanghai) Ltd.

Telephone17717235263 17717235263

Websitehttps://www.lgcstandards.com/CN/en/

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