RH01617 possesses potent inhibitory activities against Kv1.5. Kv1.5 potassium channel is reported as an efficacious and safe target for the treatment of Atrial fibrillation (AF), which is one of the common arrhythmias that threaten human health.
Uses
RH01617 is a Kv1.5. potassium channel and MMP-13 inhibitor. RH01617 can be used for research of atrial fibrillation[1][2].
References
[1] Guo X, et al. Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors. Bioorg Med Chem. 2013 Nov 1;21(21):6466-76. DOI:10.1016/j.bmc.2013.08.041 [2] Leung JM, et al. Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion. PLoS One. 2014 Jun 3;9(6):e98056. DOI:10.1371/journal.pone.0098056
