| Toxicity |
A toxic alkaloid of
the mushroom Amanita muscaria and certain other fungi.
Although useful as a pharmacological tool, muscarine has no
clinical or pesticidal applications. The compound is a potent and
selective mimic of acetylcholine at parasympathetic neuromuscular
junctions and at central muscarinic acetylcholine receptors.
Symptoms of poisoning are primarily those attributable to
peripheral parasympathetic stimulation (i.e., miosis, vomiting,
diarrhea, bradycardia, and cardiovascular collapse). The i.v.
LD50 in mice is 0.23 mg/kg.
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