2991817-99-1

MGD-4 is an orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM) in a dose-dependent manner. MGD-4 effectively inhibits the growth of multiple myeloma[1].

IKZF1: 67.2 nM (DC₅₀); IZKF2: 918.2 nM (DC₅₀); IKZF3: 95.8 nM (DC₅₀)

[1] Li P, et al. Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation[J]. Journal of Hematology & Oncology, 2024, 17(1): 77. DOI:10.1186/s13045-024-01592-z