297730-93-9

2-(Trifluoromethyl)-3-ethoxydodecafluorohexane (297730-93-9), also known as HFE-7500 or 3-ethoxy-1,1,1,2, 3,4,4,5,5,6,6,6-dodecafluoro-2-trifluoromethylhexane, is a hydrofluoroether solvent used in the chemical processing of organic electronic materials. Its physical properties make it a suitable alternative to PFCs and PFPE, and it is suitable for heat transfer applications, semiconductor manufacturing processes, the cooling of high-voltage transformers and power electronic devices, as well as pharmaceutical processes such as freeze-drying [1–3] . Furthermore, HFE-7500 is used as the primary refrigerant for preparing suspensions of metal oxide and nitride nanoparticles (such as TiO2, Al2O3, ZnO, CuO and AlN), and dissolves the surfactant Krytox 157-FSL to stabilise the dispersion system [4].

2-(Trifluoromethyl)-3-ethoxydodecafluorohexane (297730-93-9) can be used for temperature sensitive protein expression in protocells. It can also be used for light dispersion with enhanced thermal conductivity containing inorganic particles

[1] Hu, X., Meng, X., Wei, K., Li, W., Wu, J. (2015). Compressed Liquid Viscosity Measurements of HFE-7000, HFE-7100, HFE-7200, and HFE-7500 at Temperatures from (253 to 373) K and Pressures up to 30 MPa. Journal of Chemical & Engineering Data, 60(12), 3562–3570. https://doi.org/10.1021/acs.jced.5b00499
[2] Gour, N. K., Mishra, B. K., Sarma, P. J., Begum, P., Deka, R. C. (2017). Tropospheric degradation of HFE-7500[ n -C 3 F 7 CF(OCH 2 CH 3 )CF(CF 3 ) 2 ] initiated by OH radicals and Fate of alkoxy radical [ n -C 3 F 7 CF(OCH(O )CH 3 )CF(CF 3 ) 2 ]: A DFT investigation. Journal of Fluorine Chemistry, 204, 11–17. https://doi.org/10.1016/j.jfluchem.2017.09.010
[3] Muñoz-Rujas, N., Bazile, J. P., Aguilar, F., Galliero, G., Montero, E., Daridon, J. L. (2017). Speed of sound and derivative properties of hydrofluoroether fluid HFE-7500 under high pressure. The Journal of Chemical Thermodynamics, 112, 52–58. https://doi.org/10.1016/j.jct.2017.04.007
[4] Ozturk, S., Schmidt, K. (2025). Characterization of HFE 7500 Refrigerant Suspensions Containing Oxide and Nitride Nanoparticles: Thermal, Rheological, and Electrokinetic Insights. ChemEngineering, 9(4), 65. https://doi.org/10.3390/chemengineering9040065