2959444-40-5

Uses

ROS inducer 4 (compound TE3) is a mitochondrial inhibitor. ROS inducer 4 causes a series of mitochondria-related physiological changes in tumors, such as mitochondrial fragmentation, explosive generation and accumulation of ROS, decreased mitochondrial membrane potential, decreased ATP content, and activation of ROS-mediated apoptotic signaling in mitochondria[1].

in vivo

The LD50 of ROS inducer 4 (compound TE3) in C57BL/6 female mice is 70 mg/kg and the 95 % confidence interval was 59.29-97.9 mg/kg^[1].
ROS inducer 4 (1-2 mg/kg) has better anti-cervical cancer activity and safety than the Cisplatin (HY-17394), and can activate the immune response in mice^[1].
ROS inducer 4 has moderate toxicity, ROS inducer 4 does not have significant toxic effects at an effective dose (1 mg/kg)^[1].

References

[1] Liu P, et al. Mitochondrial targeted modification and anticancer mechanism of natural product ergosterol peroxide. Bioorg Chem. 2024 Jul 31;151:107688. DOI:10.1016/j.bioorg.2024.107688

Hazard Information

Uses

in vivo

References

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