PCSK9-IN-20 (Compound 3i) is a PCSK9 inhibitor with an IC50 of 3.96 μM. PCSK9-IN-20 decreases PCSK9 and increases LDLR protein expression in vitro[1].
References
[1] Zhixin Ma, et al. Identification of benzothiazoles as novel PCSK9 inhibitors. Bioorg Med Chem Lett. 2023 Nov 6:129542. DOI:10.1016/j.bmcl.2023.129542
