DNA-PK-IN-10 is a DNA-PK inhibitor. DNA-PK-IN-10 can be used for the research of breast cancer and non-small cell lung cancer[1].
in vivo
DNA-PK-IN-10 (Example 31) (30 mg/kg; administered twice a day) significantly inhibits tumor growth, and the shows good tolerance in mice were inoculated NCI-H1703 cells[1].
References
[1] Kuncheng C, et, al. Dna-pk selective inhibitor, and preparation method therefor and use thereof. WO2023036156A1.
