PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC50<0.1 μM). PROTAC SMARCA2 degrader-1 is also an E3 ubiquitin ligase binding linker useful in research of cancers. PROTAC SMARCA2 degrader-1 is a target protein ligand-linker conjugate[1].
References
[1] Lu Liang, et al. Preparation of pyridazine derivatives as BRM targeting compounds and E3 ubiquitin ligase binding agents for the treatment of cancers. World Intellectual Property Organization, WO2023287787 A1 2023-01-19.
