288847-35-8

Name	Oxi 4503
CAS	288847-35-8
Molecular Formula	C18H22O12P2
MDL Number	MFCD25976806
Molecular Weight	492.31
MOL File	288847-35-8.mol

Synonyms

CS-1521 AC1OCFKI Oxi 4503 KB-64255 Rostafuroxine UNII-JH6Z94GLUD OXI4503; OXI-4503 Oxi4503|||CA1P|||Oxi4503 CoMbretastatin A1 diphosphate Combretastatin A-1 bis(phosphate) Combretastatin A1 diphosphate|||Combretastatin A1 diphosphate CA1P; 288847-35-8; OXI-4503; AC1OCFKI; UNII-JH6Z94GLUD; COMBRETASTATIN A-1 BIS(PHOSPHATE); KB-64255 1,2-Benzenediol, 3-Methoxy-6-[(1Z)-2-(3,4,5-triMethoxyphenyl)ethenyl]-, 1,2-bis(dihydrogen phosphate)

show less show more

Chemical Properties

Boiling point	766.4±70.0 °C(Predicted)
density	1.529±0.06 g/cm3(Predicted)
form	Solid
pka	0.99±0.50(Predicted)
color	Off-white to pink

Hazard Information

Uses

Combretastatin A1 phosphate (Oxi4503; CA1P; Combretastatin A1 diphosphate) is a potent vascular disruptive agent. Combretastatin A1 phosphate exerts anti-angiogenic effects on tumors. Combretastatin A1 phosphate has the potential for the research of pancreatic neuroendocrine tumors[1][2].

in vivo

Combretastatin A1 phosphate (100 mg/kg; I.p.; once at day 16 post tumor induction) shows anti-tumor activity and exerts anti-angiogenic effects on tumors in mice when combined with Sunitinib (HY-10255A)^[2].

Animal Model:	Male CBA mice (CRC liver metastasis)^[2]
Dosage:	100 mg/kg (received 40 mg/kg of Sunitinib daily from day 14 to 21 post tumor induction)
Administration:	I.p.; once at day 16 post tumor induction
Result:	Demonstrated a significantly decreased mean liver weight compared to livers from non tumor bearing animals, significantly reduced tumor vessels.

References

[1] Patterson DM, et al. Phase I clinical and pharmacokinetic evaluation of the vascular-disrupting agent OXi4503 in patients with advanced solid tumors. Clin Cancer Res. 2012 Mar 1;18(5):1415-25. DOI:10.1158/1078-0432.CCR-11-2414
[2] Nguyen L, et al. Vascular disruptive agent OXi4503 and anti-angiogenic agent Sunitinib combination treatment prolong survival of mice with CRC liver metastasis. BMC Cancer. 2016 Jul 26;16:533. DOI:10.1186/s12885-016-2568-7

Supplier

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Related Products

54965-21-8 474645-27-7

114977-28-5 253128-41-5

646502-53-6 796073-69-3

PROMPT×

PROMPT
The What'sApp is temporarily not supported in mainland China

Cancel

Determine

Send Inquriy