2883627-64-1

α-Synuclein inhibitor 8 is an active inhibitor of α-Synuclein with an IC50 value of 2.5 μM. α-Synuclein inhibitor 8 has highly inhibition on the aggregation and disaggregation of α-Synuclein fibers. α-Synuclein inhibitor 8 reduces the formation of inclusions in neurons that can repairs damage neurons and improves Parkinson’s disease (PD)-like symptoms. α-Synuclein inhibitor 8 has high antioxidant activity and low cytotoxicity[1].

α-synuclein Aggregation

[1] Lü MH, et al. Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice. Eur J Med Chem. 2023 Jan 18;249:115122. DOI:10.1016/j.ejmech.2023.115122