28540-81-0

1-Chloro-2-iodoethylene is a cross-coupling reagent used as a precursor of chloroenynes, terminal, and unsymmetrical internal diynes.

1. Van de Walle, H.; Henne, A. Bull. Sci. Acad. Roy. Belg. 1925, 11, 360 (CA 1926, 20, 1050).

1-chloro-2-iodoethylene can be synthesized by either chloromercuration of Acetylene followed by iodinolysis or electrophilic addition of Iodine Monochloride to acetylene (eq 1).¹

1-Chloro-2-iodoethylene should be used in a fume hood.