Z36-MP5 is an Mi-2β-targeted inhibitor, with IC50 of 0.082 μM. Z36-MP5 can reduce Mi-2β ATPase activity and reactivates ISG transcription. Z36-MP5 can stimulate T-cell-mediated cytotoxicity[1].
References
[1] Cang Li, et al. Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation. Nat Commun. 2024 Mar 9;15(1):2163. DOI:10.1038/s41467-024-46422-5
