28189-85-7

Name	Etoxadrol
CAS	28189-85-7
Molecular Formula	C16H23NO2
MDL Number	MFCD00864446
Molecular Weight	261.36
MOL File	28189-85-7.mol

Synonyms

Nsc288020 Etoxadrol Piperidine, 2-(2-ethyl-2-phenyl-1,3-dioxolan-4-yl)- Piperidine, 2-(2-ethyl-2-phenyl-1,3-dioxolan-4-yl)-, (+)- (S)-2-[(2S)-2-Ethyl-2α-phenyl-1,3-dioxolan-4β-yl]piperidine Piperidine, 2-[(2S,4S)-2-ethyl-2-phenyl-1,3-dioxolan-4-yl]-, (2S)-

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Chemical Properties

Boiling point	404.61°C (rough estimate)
density	1.0086 (rough estimate)
refractive index	1.5500 (estimate)
pka	9.57±0.10(Predicted)
Water Solubility	0.65g/L(20 ºC)

Hazard Information

Uses

Etoxadrol (CL-1848C) is a potent, high-affinity N-methyl-D-aspartic acid (NMDA) antagonist. Etoxadrol is used in the anaesthetic and anaesthesia research community to suppress or relieve pain[1].

in vivo

Etoxadrol (CL-1848C) (100.0 mg/kg; i.h.; once) produces marked stimulation and ataxia in mice^[2].
Etoxadrol (0-20 mg/kg; i.v.; once) decreases brain monoamine concentrations after 4 h injection^[3].

Animal Model:	Carworth-Farm (Upjohn) male mice weighing 18 to 20 gm^[2]
Dosage:	100.0 mg/kg
Administration:	Subcutaneous injection, 30 min
Result:	Produced marked stimulation and ataxia.

Animal Model:	Male CFE rats weighing 110-175 g (average 130 g)^[3]
Dosage:	5, 10, and 20 mg/kg
Administration:	Intravenous injection, once
Result:	Significantly lowered brain serotonin, DA (dopamine), and NE (norepinephrine) concentrations at 4 h.

References

[1] A Thurkauf, et al. Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist. J Med Chem. 1988 Dec;31(12):2257-63. DOI:10.1021/jm00120a004
[2] A H Tang, et al. Analgetic activities of etoxadrol in the rhesus monkey and in mice. Anesth Analg. 1973 Jul-Aug;52(4):577-83. PMID:4197876
[3] Y F Sung, et al. Effects of intravenous anesthetics on brain monoamines in the rat. Anesthesiology. 1973 Nov;39(5):478-87. DOI:10.1097/00000542-197311000-00004

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