2772949-38-7

Name	Octanamide, N-cyclopropyl-8-[3-(1,1-dimethylheptyl)-5-methoxyphenoxy]-
CAS	2772949-38-7
Molecular Formula	C27H45NO3
Molecular Weight	431.65
MOL File	2772949-38-7.mol

Synonyms

CB1/2 agonist 4 Octanamide, N-cyclopropyl-8-[3-(1,1-dimethylheptyl)-5-methoxyphenoxy]-

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Chemical Properties

Boiling point	586.2±50.0 °C(Predicted)
density	1.00±0.1 g/cm3(Predicted)
pka	16.22±0.20(Predicted)

Hazard Information

Uses

CB1/2 agonist 4 is a full CB1 agonist and CB2 partial agonist with EC50 values of 15.09 nM and 1.16 nM, respectively. CB1/2 agonist 4 also has hCB1 and hCB2 receptor affinities with Ki values of 1.1 nM and 4.2 nM, respectively. CB1/2 agonist 4 has a significant antinociceptive activity, and also can activate cannabinoid and TRPV1 receptor with values of IC50 and EC50 is 0.8 μM and 0.12 μM, respectively[1].

in vivo

CB1/2 agonist 4 (compound 24) (1, 3 and 4 mg/kg, i.p.) has a stronger antinociceptive activity^[1].
CB1/2 agonist 4 (1, 3 and 4 mg/kg, i.p.) can activate TRPV1 channel and it behaved as a good TRPV1 agonist with an IC₅₀ value of 0.8 μM and EC₅₀ value of 0.12 μM^[1].

Animal Model:	Male CD-1 outbred mice^[1]
Dosage:	1, 3 and 4 mg/kg
Administration:	1, 3 and 4 mg/kg, i.p.
Result:	Significantly reduced the late phase of formalin-induced nociceptive behaviour in a dose dependent manner and slightly decreased also the first phase of nociceptive response.

References

[1] Antonella Brizzi, et al. Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity. Bioorg Med Chem. 2020 Jun 1;28(11):115513. DOI:10.1016/j.bmc.2020.115513

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Websitehttp://www.cw-bio.com

TargetMol Chemicals Inc.

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Websitehttps://www.targetmol.cn/

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