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Pomalidomide 4'-alkylC4-azide (Compound 2) is an azide compound containing a MIDI group and is one of the compounds used to construct a library of MIDI azide compounds. Pomalidomide 4'-alkylC4-azide can be used to develop research on PROTAC degraders[1].

Pomalidomide 4'-alkylC4-azide is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus an alkylC4 linker with terminal azide ready for conjugation to a target protein ligand.

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[1] Liu H,et al. Construction of an IMiD-based azide library as a kit for PROTAC research[J]. Organic & Biomolecular Chemistry, 2021, 19(1): 166-170. DOI:10.1039/d0ob02120b