2749807-20-1

Cinacalcet-d3 is intended for use as an internal standard for the quantification of cinacalcet (Item No. 16042) by GC- or LC-MS. Cinacalcet is a calcimimetic and an allosteric agonist of the calcium-sensing receptor (CaSR; EC50 = 79.4 nM in HEK293T cells expressing the human receptor).1 In vivo, cinacalcet (0.1-10 mg/kg, s.c.) decreases plasma levels of parathyroid hormone (PTH) in rats. It also decreases plasma levels of PTH and parathyroid cell proliferation in a mouse model of primary hyperparathyroidism.2 Formulations containing cinacalcet have been used in the treatment of secondary hyperparathyroidism due to end-stage renal disease and hypercalcemia in patients with parathyroid carcinoma.WARNING This product is not for human or veterinary use.

[1] JIAN-NONG MA. Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor.[J]. Journal of Pharmacology and Experimental Therapeutics, 2011, 337 1: 275-284. DOI: 10.1124/jpet.110.178194
[2] YASUO IMANISHI. Cinacalcet HCl suppresses Cyclin D1 oncogene-derived parathyroid cell proliferation in a murine model for primary hyperparathyroidism.[J]. Calcified Tissue International, 2011, 89 1: 29-35. DOI: 10.1007/s00223-011-9490-4