2749394-82-7

JWH 081 N-pentanoic acid metabolite-d5 (Item No. 14362) is intended for use as an internal standard for the quantification of JWH 081 N-pentanoic acid metabolite (Item No. 14353) by GC- or LC-MS. JWH 081 (Item No. 10579) is a cannabimimetic indole related to JWH 015 (Item No. 10009018) and JWH 018 (Item No. 10900) that shows preference for the central cannabinoid (CB1) receptor (Ki = 1.2 nM) over the peripheral cannabinoid (CB2) receptor (Ki = 12.4 nM).1,2 JWH 081 N-pentanoic acid metabolite is an expected metabolite of JWH 081 that would be detectable both in serum and in urine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic purposes.WARNING This product is not for human or veterinary use.

[1] MIE MIE AUNG . Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding[J]. Drug and alcohol dependence, 2000, 60 2: Pages 133-140. DOI: 10.1016/s0376-8716(99)00152-0
[2] JOHN W. HUFFMAN . Structure–activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists[J]. Bioorganic & Medicinal Chemistry, 2005, 13 1: Pages 89-112. DOI: 10.1016/j.bmc.2004.09.050