2749281-71-6

Name	Methanone, 1-piperidinyl[4,5,6,7-tetrahydro-1-propyl-5-[[2-(4-pyridinyl)ethyl]amino]-1H-indazol-3-yl]-, hydrochloride (1:2)
CAS	2749281-71-6
Molecular Formula	C23H34ClN5O
Molecular Weight	432.01
MOL File	2749281-71-6.mol

Synonyms

Methanone, 1-piperidinyl[4,5,6,7-tetrahydro-1-propyl-5-[[2-(4-pyridinyl)ethyl]amino]-1H-indazol-3-yl]-, hydrochloride (1:2)

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Chemical Properties

solubility	DMSO: Soluble
form	Solid
color	Light yellow to yellow

Hazard Information

Uses

NUCC-390 dihydrochloride is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 dihydrochloride induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046)[1]. NUCC-390 dihydrochloride promotes nerve recovery of function after neurodegeneration in vivo[2].

in vivo

NUCC-390 dihydrochloride (hind limb injection; 3.2 mg/kg; twice daily; 3 days) contributes to the functional and anatomical recovery of the neuromuscular junction (NMJ) following an acute nerve terminal damage by α-LTx in CD-1 mice^[2].

Animal Model:	Six to eight-week-old CD1 mice^[2]
Dosage:	3.2 mg/kg
Administration:	Hind limb injection; twice daily; 3 days
Result:	Promoted functional and anatomical recovery of the NMJ.

IC 50

CXCR4

References

[1] Mishra RK, et al. Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonists.Sci Rep. 2016 Jul 26;6:30155. DOI:10.1038/srep30155

Supplier

Shanghai Beckham Medical Technology Co., Ltd

Telephone 13816613772

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 15026964105

Websitehttps://www.shyuanye.com

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Telephone4000862158 18117107507

Websitehttps://www.med-life.cn/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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