2748247-26-7

Chlorambucil-d8 is intended for use as an internal standard for the quantification of chlorambucil (Item No. 23744) by GC- or LC-MS. Chlorambucil is a DNA alkylating agent.1 It induces DNA cross-linking in vitro when used at a concentration of 1 mg/ml and preferentially targets guanine-rich regions. Chlorambucil (8 and 15 mg/kg) is teratogenic in vivo, reducing fetal brain size and inducing microcephaly when administered to pregnant mice.2 Formulations containing chlorambucil have been used in the treatment of various cancers.WARNING This product is not for human or veterinary use.

[1] DALIA MOHAMED. Chlorambucil-Adducts in DNA Analyzed at the Oligonucleotide Level Using HPLC-ESI MS[J]. Chemical Research in Toxicology, 2009, 22 8: 1435-1446. DOI: 10.1021/tx900123r
[2] OSAMU TANAKA. Effects of Chlorambucil on the Brain Development in Mice during Post-neurulation Period[J]. Congenital Anomalies, 1991, 31 3: 141-152. DOI: 10.1111/j.1741-4520.1991.tb00759.x