2747918-66-5

Clevidipine-d7 is intended for use as an internal standard for the quantification of clevidipine (Item No. 23025) by GC- or LC-MS. Clevidipine is an inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes).1 It preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively).2 Clevidipine decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats with ED30 values of 316 and 58 nmol/kg, respectively. Formulations containing clevidipine have been used in the treatment of hypertension.WARNING This product is not for human or veterinary use.

[1] X YI  C L  B Vivien. Clevidipine blockade of L-type Ca2+ currents: steady-state and kinetic electrophysiological studies in guinea pig ventricular myocytes.[J]. Journal of Cardiovascular Pharmacology, 2000, 36 5: 592-600. DOI: 10.1097/00005344-200011000-00008
[2] MARGARETA NORDLANDER. Pharmacodynamic, Pharmacokinetic and Clinical Effects of Clevidipine, an Ultrashort-Acting Calcium Antagonist for Rapid Blood Pressure Control[J]. Cardiovascular Therapeutics, 2006, 22 3: 227-250. DOI: 10.1111/j.1527-3466.2004.tb00143.x