2747917-37-7

Crotonyl fentanyl-d5 (Item No. 25132) is intended for use as an internal standard for the quantification of crotonyl fentanyl (Item No. 22801) by GC- or LC-MS. Crotonyl fentanyl is categorized as an opioid.1,2,3 It induces generalized responses in mice trained to discriminate oxycodone from saline.4 Crotonyl fentanyl-d5 is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.WARNING This product is not for human or veterinary use.

[1] AMY J. ESHLEMAN . Affinity, potency, efficacy, selectivity, and molecular modeling of substituted fentanyls at opioid receptors[J]. Biochemical pharmacology, 2020, 182: Article 114293. DOI: 10.1016/j.bcp.2020.114293
[2] LAKSHMI VASUDEVAN . Assessment of structure-activity relationships and biased agonism at the Mu opioid receptor of novel synthetic opioids using a novel, stable bio-assay platform[J]. Biochemical pharmacology, 2020, 177: Article 113910. DOI: 10.1016/j.bcp.2020.113910
[3] NEIL B. VARSHNEYA . Opioid-like antinociceptive and locomotor effects of emerging fentanyl-related substances[J]. Neuropharmacology, 2019, 151: Pages 171-179. DOI: 10.1016/j.neuropharm.2019.03.023
[4] D. MATTHEW WALENTINY  Patrick M B  Léa T Moisa. Oxycodone-like discriminative stimulus effects of fentanyl-related emerging drugs of abuse in mice[J]. Neuropharmacology, 2019, 150: Pages 210-216. DOI: 10.1016/j.neuropharm.2019.02.007