Uses
BAY-390 is a selective, across species active and brain penetrating TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50s of 16, 82, 63 and 35 nM, respectively. BAY-390 can be used for the research of inflammation[1].
Biological Activity
BAY-390 is an orally activepotent and selective TRPA1 inhibitor (cellular Ca++ influx IC50 in nM by FLIPR = 16/hu19/monkey63/rat68/guinea pig73/mu81/dog; IC50 = 5.6 μM/hTRPC5>25 μM/human TRPV1/4TRPC3/6KCNK9 (TASK-3)CACNA1H (Cav3.2)) th at shows in vivo efficacy in animal models of inflammatory pain (30 or 90 mg/kg micep.o.) and neurogenic pain (30 or 90 mg/kg ratsb.i.d. p.o.).
