Description
17(S)-HDHA-d
5 is intended for use as an internal standard for the quantification of 17(S)-HDHA by GC- or LC-MS. (±)17-HDHA is formed
via autooxidation of docosahexaenoic acid (DHA) .
1 17(S)-HDHA is formed from DHA by 15-lipoxygenase (15-LO) and is a precursor in the formation of 17(S)-resolvin D1 .
2 17(R)-HDHA is formed by aspirin-acetylated COX-2-mediated oxidation of DHA and is a precursor in the formation 17(R)-resolvin D1 .
References
1. VanRollins, M., and Murphy, R.C. Autooxidation of docosahexaenoic acid: Analysis of ten isomers of hydroxydocosahexaenoate J. Lipid Res. 25(5),507-517(1984).
2. Sun, Y.P., Oh, S.F., Uddin, J., et al. Resolvin D1 and its aspirin-triggered 17R epimer stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation J. Biol. Chem. 282(13),9323-9334(2007).
