ChemicalBook CAS DataBase List 2729996-45-4

2729996-45-4

Name	INDEX NAME NOT YET ASSIGNED
CAS	2729996-45-4
Molecular Formula	C26H22FN5O2
Molecular Weight	455.49
MOL File	2729996-45-4.mol

Chemical Properties

density	1.27±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 50 mg/mL (109.77 mM; ultrasonic and warming and heat to 80°C)
form	Solid
pka	11.77±0.70(Predicted)
color	Off-white to light yellow

Hazard Information

Uses

GNE-9815 (compound 7) is a highly selective, pan-RAF inhibitor with good oral bioavailability. GNE-9815 exhibits Ki values of 0.062 and 0.19 nM for CRAF and BRAF, respectively. GNE-9815 combines with MEK inhibitor Cobimetinib (HY-13064) shows synergistic modulation of MAPK pathway. GNE-9815 can be used in studies of KRAS mutant cancers[1].

in vivo

GNE-9815 (15 mg/kg; p.o.; single) demonstrates synergistic MAPK pathway modulation when combines with the MEK inhibitor Cobimetinib in an HCT116 xenograft mouse model^[1].
GNE-9815 (5 mg/kg; p.o.; single) shows good oral bioavailability and (1 mg/kg; i.v.; single) exhibits low blood clearance, moderate volume of distribution, and short half-life^[1].

Animal Model:	Female NCR nude mice (6 to 8-week-old; 24-26 g; HCT116 xenograft mice model)^[1].
Dosage:	15 mg/kg
Administration:	Intravenous injection or oral administration; single.
Result:	Resulted in pathway inhibition as demonstrated by partial inhibition of pRSK between 2 and 24 h, but more robust, albeit transient, inhibition of the downstream MAPK target genes, DUSP6 and SPRY4. Led to deeper inhibition of the downstream MAPK target genes DUSP6 and SPRY4, when combined with the MEK inhibitor Cobimetinib, with maximal inhibition at 8 h and with a more modest rebound in levels at 24 h, post final dose.

Animal Model:	Female NCR nude mice (6 to 8-week-old; 24-26 g)^[1].
Dosage:	1 mg/kg (for i.v.); 5 mg/kg (for p.o.).
Administration:	Intravenous injection or oral administration; single.
Result:	Exhibited CL_b, V_dss and t_1/2 values of 17 mL/min?kg, 1.7 L/kg and 1.9 h, respectively. Showed good oral bioavailability with F% of 37%. (methylcellulose/Tween formulation).

IC 50

CRAF: 0.062 nM (Ki); Braf: 0.19 nM (Ki)

References

[1] Huestis MP, et al. Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor. ACS Med Chem Lett. 2021 Apr 21;12(5):791-797. DOI:10.1021/acsmedchemlett.1c00063

Spectrum Detail

Supplier

Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

Telephone 15317229551

Websitehttps://www.ureiko.com

Shanghai Beckham Medical Technology Co., Ltd

Telephone 13816613772

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 13636370518

Websitehttps://www.shyuanye.com

Shanghai Chaolan Chemical Technology Center

TelephoneQQ：65489617 13301690235

Websitehttp://www.atkchemical.com/

Shanghai Dongyang Biotechnology Co., Ltd.

Telephone0512-13601744364 13601744364

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1201937/0_EN.htm

Bide Pharmatech Ltd.

Telephone400-1647117 13681763483

Websitehttps://www.bidepharm.com/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Nanjing Shizhou Biology Technology Co.,Ltd

Telephone025-85560043 15850508050

Websitehttp://www.synzest.com

RD International Technology Co., Limited

Telephone 18024082417

Websitehttps://www.ruidiresearch.com

Sangon Biotech (Shanghai) Co.,Ltd.

Telephone400-821-026

Websitehttp://www.sangon.com

Selleck Chemicals

Telephone400-668-6834

Websitehttp://www.selleckchem.com

Shenzhen Zuoke Biotechnology Co., Ltd.

Telephone13532174601

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1018526/0_EN.htm

Guangzhou Kegou Biotechnology Co., Ltd.

Telephone18689410811

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList632156/0_EN.htm

1of3

Send Inquriy