2722697-82-5

MC-VC-PABC-amide-PEG1-CH2-CC-885 (compound I-1) is a neoDegrader-Linker conjugate, consists of the GSPT1 degrader/molecular glue CC-885 (HY-101488) and a linker. MC-VC-PABC-amide-PEG1-CH2-CC-885 can be conjugated to the antibody DAR3.7 that specifically targets CD56 to synthesize Antibody-Drug Conjugates (ADCs)[1].

[1] Mary E. Matyskiela, et al. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature. 2016 Jul 14;535(7611):252-7. DOI:10.1038/nature18611
[2] Neodegrader conjugates. World Intellectual Property Organization, WO2021198965 A1 2021-10-07.
[3] Neodegrader conjugates. World Intellectual Property Organization, WO2024075080 A1 2024-04-11.