2651994-75-9

CypD-IN-3 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-3 has CypD affinity with an IC50 value of 0.01 μM. CypD-IN-3 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes[1].

Cyclophilin D: 0.01 μM (IC₅₀); Cyclophilin A: 1.1 μM (IC₅₀); Cyclophilin B: 0.21 μM (IC₅₀); Cyclophilin E: 0.31 μM (IC₅₀)

[1] Alexander A Peterson, et al. Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat Chem Biol. 2022 Sep 26. DOI:10.1038/s41589-022-01116-1