264622-53-9

MRS1706 is a selective adenosine A_2B receptor inverse agonist with K_i values of 1.39, 157, 112, and 230 nM for human A_2B, A₁, A_2A, and A₃ receptors, respectively.

MRS 1706 is a selective and potent Adenosine A2B-R inverse agonist Ki (binding affinity) values of 1.39, 157, 112, and 230 nM for human A2B, A1, A2A, and A3 receptors, respectively.

Potent and selective adenosine A 2B receptor inverse agonist (K i values are 1.39, 157, 112 and 230 nM for human A 2B , A 1 , A 2A and A 3 receptors respectively).

[1] YONG-CHUL KIM. Anilide Derivatives of an 8-Phenylxanthine Carboxylic Congener Are Highly Potent and Selective Antagonists at Human A2B Adenosine Receptors[J]. Journal of Medicinal Chemistry, 2000, 43 6: 1165-1172. DOI: 10.1021/jm990421v
[2] QILAN LI. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor.[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 320 2: 637-645. DOI: 10.1124/jpet.106.111203