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Celecoxib carboxylic acid acyl-β-D-glucuronide is a phase II metabolite of celecoxib . Celecoxib is an anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits cyclooxygenase-2 (COX-2; IC₅₀s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively). Celecoxib carboxylic acid acyl-β-D-glucuronide is a minor metabolite, accounting for 2% of the administered dose in human urine and rat bile.

Celecoxib Carboxylic Acid Acyl-β-D-glucuronide is a glucuronide metabolite of Celecoxib (C251000), a Cox-2 inhibitor.

[1] S K PAULSON. Metabolism and excretion of [(14)C]celecoxib in healthy male volunteers.[J]. Drug Metabolism and Disposition, 2000, 28 3: 308-314.
[2] YONG MA  Ming H  Song Gao. Quantitation of celecoxib and four of its metabolites in rat blood by UPLC-MS/MS clarifies their blood distribution patterns and provides more accurate pharmacokinetics profiles[J]. Journal of Chromatography B, 2015, 1001: Pages 202-211. DOI: 10.1016/j.jchromb.2015.07.026
[3] Y. AMY SIU . Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variants[J]. Drug Metabolism and Pharmacokinetics, 2018, 33 5: Pages 219-227. DOI: 10.1016/j.dmpk.2018.06.001